LEI 11684 PDF

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Efficacy and safety of treatment with an anti-m2e monoclonal antibody in experimental human influenza. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Immunization with high epitope density of M2e derived from pandemic H1N1 elicits protective immunity in mice. Journal of Orthopaedic Surgery and Research.

Synthesis, phase transformation and bioassay study. Bisphenol AP is anti-estrogenic and may cause adverse effects at low doses relevant to human exposure. Porcine epidemic diarrhea virus S1 protein is the critical inducer of apoptosis.

Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses

Ekiert DC, et al. IgG2a ratio Supplementary Fig. Vaccinations with the resulting protein nanoparticles in mice induces robust long-lasting immunity, fully protecting the mice against challenges by divergent influenza A viruses of the same group or both groups.

Nanotechnology, Biology, and Medicine. Stabilization of zwitterionic versus canonical proline by water molecules. Chinese Journal of Natural Medicines. The case of Wuxi. Identification of metabolites in human and rat urine after oral administration of Xiao-Qing-Long-Tang granule using ultra high performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry. PNps were made as previously described with modification Design of head-removed HA recombinant proteins According to previous results, trimerization motifs facilitate HA oligomerization in the absence of the HA transmembrane domain 17 Preliminary SAR and biological evaluation of antitubercular triazolothiadiazine derivatives against drug-susceptible and drug-resistant Mtb strains.


The generation of hrHA representatives from both phylogenetic groups is essential to formulate a vaccine that can elicit a genuinely universal protective response. Representative headless HAs of two HA phylogenetic groups are constructed and purified. Either your web browser doesn’t support Javascript or it is currently turned off. The HA1 domain is shown in green-cyan and the HA2 domain is shown in blue.

A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve. All other authors have no potential conflict of interest.

Occurrence, spatiotemporal distribution, and ecological risks of steroids in a large shallow Chinese lake, Lake Taihu. The squares besides HA subtypes indicate HA phylogenetic groups by coloring: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Structure and function analysis of an antibody recognizing all influenza A subtypes. The lowest serum dilution able to inhibit virus hemagglutination is shown. Left ventricular energy loss and wall shear stress assessed by vector flow mapping in patients with hypertrophic cardiomyopathy.

Experimental and Molecular Pathology. Activation of CO2-reducing methanogens in oil reservoir after addition of nutrient.

Besides direct viral NT, Fc-mediated effector mechanisms such 11684 antibody dependent cellular cytotoxicity ADCC contribute substantially to protection against influenza challenges 10 Comparison of fibrin glue and Vicryl sutures in conjunctival lej for pterygium surgery.


SIRT2 is an unfavorable prognostic biomarker in patients with acute myeloid leukemia. We fabricated PNps approximately the size of the influenza A virions with a core of M2e displaying a shell of conserved hrHA domains. Kanekiyo M, et al. High expression of ETS2 predicts poor prognosis in acute myeloid leukemia and may guide treatment decisions.

Differences of the in vivo and lel vitro metabolism of imrecoxib in humans: Data are representative from two independent experiments. Incorporating catechol into electroactive polypyrrole nanowires on titanium to promote hydroxyapatite formation.

The Journal of Infectious Diseases. Zhou Let al.

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In this study, we found that layered PNps composed of structure-stabilized HA stalk domains from both HA groups, and novel constructed M2e, are highly immunogenic to induce immune protection against homosubtypic and heterosubtypic influenza A virus challenges.

The effects of nonsteroidal anti-inflammatory drugs in the incident and recurrent risk of hepatocellular carcinoma: A promising approach is to express a standalone HA stalk domain without the highly immunogenic and strain-specific head domain, and a stabilized M2e with high epitope density. Natural variation in CTB4a enhances rice adaptation to cold habitats.