FELBAMATE PACKAGE INSERT PDF

See package insert. How to take and store Felbamate? Follow your doctor’s directions. Call if you have any questions. Usually, your doctor will tell you to start by. Felbatol is the brand name used in the United States for felbamate. Read the black box warning in the Package Insert to your patient and obtain any necessary . Felbamate, also known as Felbatol, has been approved by the Food and Drug about all potential risks before using this drug and read the package insert.

Author: Nekasa Tobei
Country: Denmark
Language: English (Spanish)
Genre: Spiritual
Published (Last): 7 December 2004
Pages: 309
PDF File Size: 15.48 Mb
ePub File Size: 7.4 Mb
ISBN: 711-7-68324-497-4
Downloads: 20348
Price: Free* [*Free Regsitration Required]
Uploader: Nalkree

Serum concentrations of other anticonvulsants should be obtained and dosage adjustments made as necessary. Major Avoid coadministration of ivabradine and felbamate. Plasma concentrations of darunavir may be reduced if these drugs are administered concurrently, leading to a reduction of antiretroviral felbmaate and the potential development of viral resistance.

Hydroxychloroquine can lower the seizure threshold; therefore, the activity of antiepileptic drugs may be impaired with concomitant use. If not possible, closely monitor for increased side effects of doxorubicin including myelosuppression and cardiotoxicity.

Decreased serum concentrations of vorapaxar and thus decreased efficacy are possible when vorapaxar, a CYP3A4 substrate, is coadministered with felbamate, a mild CYP3A inducer. Valproic Acid, Divalproex Sodium: Avoid coadministration inxert felbamate and doxorubicin if possible.

Amphetamines may decrease the seizure threshold and may increase the risk of seizures. Plasma concentrations of atazanavir may be reduced if these drugs are administered concurrently, leading to a reduction of antiretroviral efficacy and the potential innsert of viral resistance.

While frequent monitoring of liver function tests may increase pakage likelihood of early detection, the precise schedule for monitoring is a matter of clinical judgement. Major Felbamate may reduce the antiplatelet activity of clopidogrel by inhibiting clopidogrel’s metabolism to its active metabolite. If these drugs must be administered together, closely monitor for a reduction in dapsone efficacy and signs of hemolytic anemia.

An alternate or additional form of contraception should be used during concomitant treatment. Moderate Trazodone can lower the seizure threshold of anticonvulsants, although the overall risk is low at therapeutic doses. Moderate MAOIs can cause a variable change in seizure patterns, so careful monitoring of the patient with epilepsy is required.

  BRIEF APPLIED CALCULUS BERRESFORD 6TH EDITION PDF

Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required. Coadministration is expected to decrease the plasma concentration of dapsone and increase the formation of dapsone hydroxylamine a metabolite associated with hemolysis.

Loperamide is metabolized by the hepatic enzyme CYP3A4; felbamate is a mild inducer of this enzyme. The intended therapeutic effect of clarithromycin could be decreased. If seizures occur, amphetamine discontinuation may be necessary. Whether pre-existing hepatic disease increases the risk of felbamate-induced hepatotoxicity is unknown. It should be noted that results of a population pharmacokinetic analysis showed that concurrent use of felbamate and clobazam did innsert significantly alter the kinetics of clobazam or its active metabolite at steady-state.

When an anticonvulsant is being used to manage behavior, stabilize mood, or treat a psychiatric disorder, the facility should attempt periodic tapering of the medication packaeg provide documentation of medical necessity in accordance with OBRA guidelines.

Felbatol (felbamate) dose, indications, adverse effects, interactions from

Seizures are believed to be initiated and propagated by stimulation of the NMDA receptor, which may be regulated by activation of a receptor-gated calcium ion channel. While the OH-clarithromycin active metabolite concentrations are increased, this metabolite has different antimicrobial activity compared to clarithromycin. However, this is considered to be a class pakcage. The effect of felbamate on labor and delivery in humans is unknown. Moderate If concurrent use of cobimetinib and felbamate is necessary, use caution and monitor for decreased efficacy of cobimetinib.

Kava Insegt, Piper methysticum: The use of felbamate is associated with a marked increase in the incidence of aplastic anemia pancytopenia in the presence of a bone marrow largely depleted of hematologic precursor cells. The need for indefinite continuation in treating any condition should be based on confirmation of the condition and its potential cause s. The knsert of food on GI absorption from the oral suspension has not been evaluated.

Moderate Additive CNS depression can occur if ethanol is consumed while taking felbamate. If a felbamatf baby experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA. Major Coadministration of felbamate and clarithromycin may decrease clarithromycin serum concentrations due to CYP3A4 enzyme induction.

  ACECLOFENAC PARACETAMOL SERRATIOPEPTIDASE PDF

Clinical signs and symptoms may include infection, bleeding, or anemia. In addition, seizures have been inssert during the use of molindone, which is of particular significance in patients with a seizure disorder receiving anticonvulsants.

Moderate The plasma concentration and efficacy of loperamide may be reduced when administered concurrently with felbamate.

Major Coadministration of felbamate with cobicistat is not recommended. Any patient withdrawn from the drug for liver injury are considered at increased risk for such problems if the drug is re-introduced. Felbamate may interfere with valproic acid metabolism and should be administered cautiously to patients receiving valproic acid.

PDR Search

Patients who experience breakthrough bleeding while receiving these drugs together should notify their prescribers. Therefore, use of praziquantel with felbamate, a CYP3A4 inducer, should be done with caution as concomitant use may produce therapeutically ineffective concentrations of praziquantel.

Oral dosage-Conversion to Monotherapy. There were 4 completed suicides among patients in drug treatment groups versus none in the placebo groups. Moderate Felbamate has been shown to increase valproic acid serum concentrations, however the magnitude of this effect iinsert.

Hepatic disease, hepatitis, hepatotoxicity, jaundice. Agranulocytosis, aplastic anemia, bone marrow suppression, hematological disease, leukopenia, neutropenia, thrombocytopenia. In addition, as a result of the synthesis process, felbamate could contain small amounts of two known animal felbzmate, the genotoxic paclage ethyl carbamate urethane and the non-genotoxic compound methyl carbamate. Moderate Concurrent use of topiramate and drugs that cause thrombocytopenia such as the anticonvulsant felbamate may increase the risk of bleeding.

Minor Coadministration of rivaroxaban and felbamate may result in decreased rivaroxaban exposure and may decrease the efficacy of rivaroxaban.