This is an important contribution, adding to the understanding of bone remodeling, which is not just relevant to arthritis but also to degenerative bone changes. Degenerative and inflammatory joint diseases lead to a destruction of the joint architecture. Whereas degenerative osteoarthritis results in the formation of new . Figure 3 New bone formation next to inflamed joints is increased upon blockade of DKK (a) Microphotographs of toluidine blue–stained joint sections of, ”from.

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WalshTania N. Gravallese Arthritis and rheumatism References Publications referenced by this paper. You are an Editor for the journal in which the article is published. Figure 3 New bone formation next to inflamed joints is increased upon blockade of DKK We identified tumor necrosis factor-alpha TNF as a key inducer of DKK-1 in the mouse inflammatory arthritis model and in human rheumatoid arthritis. Wound scratching was used to induce the migration of FLSs [ 26 ]. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.

The binding of integrins to ECM proteins activates diverse non-receptor protein tyrosine kinase signalling pathways, including the FAK, c-Src and Syk pathways. Showing of extracted citations.

Dickkopf-1 is a master regulator of joint remodeling

Role of pactivated kinase 1 in regulating the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients. User comments must be in English, comprehensible and relevant to the article under discussion. The use of certain tools provided by this website is subject to additional Terms and Conditions. HolmenTroy A. Immunoblotting was performed as described previously [ 27 femodeling.

He Therapeutic advances in musculoskeletal disease As shown in Fig. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. HolmenTroy A. Topics Discussed in This Paper. Binding of paxillin to alpha4 integrins modifies integrin-dependent rrgulator responses. PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis.


By posting Material you grant to F an irrevocable non-exclusive royalty-free license to keep a copy of Material for a reasonable period and as necessary to enable it to comply with its legal obligations. He Therapeutic advances in musculoskeletal disease Citing articles via Web of Science Black arrows indicate areas of proteoglycan deposition.

Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid arthritis leads to bone resorption. Gravallese Immunological reviews Autoantibodies in neuropsychiatric lupus: Statistical analysis for the difference in each condition was performed using a xickkopf-1 Mann—Whitney U test between two groups.

Dickkopf-1 is a master regulator of joint remodeling. – FPrime

Consistent with the gene expression data, western blot analysis showed dickkopv-1 high level of DKK-1 protein expression at 24 h after wound scratching, whereas a lower level of DKK-1 protein was produced in OA FLSs. Gravallese Calcified Tissue International Rheumatoid Dicmkopf-1 Search for additional papers on this topic. You are a close professional associate of any of the authors e. These discrepancies might result from the variety of diseases and cellular conditions that have been studied.

Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis R. Receive exclusive offers and updates from Oxford Academic. Dickkopf-1 stimulates fibroblast-like synoviocyte migration through Janus kinase activation [abstract]. Any view or opinion expressed in any Material is the view or opinion of the person who posts such view or opinion.

Methotrexate achieves major cDAPSA response, and improvement in dactylitis and functional status in psoriatic arthritis. F does not screen, edit, publish or review Material prior to its appearance on the website and is not responsible for it.


Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells. In addition, we found that WAYtreated and SPtreated RA FLSs exhibited significantly reduced expression of p-JNK and paxillin, in addition to reduced cell migration, although the off-target effect of these inhibitors could not be clearly excluded.


Citations Publications citing this paper.

Dickkopf-1 is a master regulator of joint remodeling – Semantic Scholar

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They were all female patients and provided written informed consent. Showing of 34 references. Specifically, JNK-mediated phosphorylation of serine in paxillin was shown to be required for enhanced cell migration [ 21 ]. Register for day free trial Registration is free and only takes a moment, or subscribe for unlimited access. You expect to receive, or in the past 4 years have received, shared grant support or other funding with any of the authors.

WISPers about modulation of osteoarthritis. Melissa M MatzelleMaxime A.