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Severe preexisting visual disturbance section 8.

Disseminated disease is recorded, but children are treated according to their main therapy subgroup determined by NF I-status and tumor site. Analysis of prognostic factors Results given for the various trials, SIOP – LGG 1 included, are data derived from quite heterogeneous groups of children affected by a low grade glioma.

First Grade Math and Literacy Printables – BUNDLE – 10 months

As said, it is very difficult to compare these data, considering the many factors, which can influence the decision of irradiating a child.

The contribution of the major European Pediatric Neuro-oncology Groups — e.

The further treatment for the 43 patients who had allergic reactions to Carboplatin was: Alterations in blood supply, decelerating growth kinetics within the tumor over time due to a change in the ability of the tumor to maintain an adequate level of autocrine growth factors like EGF-receptor, c-erbB-2 oncoprotein, TGF-alpha or an increase in the spontaneous rate of apoptosis could contribute to the stable situation Bodeyvon BossanyRhodes Radiotherapy When adjuvant treatment is indicated, radiotherapy can be the first line bid in case of a small residuum amenable to stereotactic or conformal bix.

Endocrine investigations – as detailed on next page. Older patients 8 years and older: Thus, the radiotherapyfree interval has been proposed as a criteria for judging the effect of chemotherapy. These tumors occur at all ages. Data transfer between the national study offices and the international trial office confers to regulations of data security see section The images must be sent in for central radiologic review in all children entering the randomised arm of the chemotherapy trial.


The controversy concerning tumor management with radical or conservative surgery even for children with midline supratentorial glioma in order to reduce the rate of progression has to take postoperative functional status into consideration, as well WisoffSuttonHoffman Basic Protocol Scheme All patients with low grade glioma, eligible according to the criteria from section 9.

Frau Locke – Grundschultante

Radiotherapy options should be discussed with the national radiotherapy reference center. Gnekow, Silvia Soellner I. Dies man entweder auf der Kartei mit Folienstift oder im Heft erledigen. According to individual decisions even older children may receive primary chemotherapy.

Zahlemraum children, who upon indication for non-surgical therapy will receive external beam radiotherapy, will be irradiated with 54 Gy tumor dose conventionally fractionated at 1,8 Gy given on five days per week.

The criteria for classification are based upon the WHO classification in its current, revised version including the grading system Kleihues Viele verschiedene Motive findest du im zahlenrahm Bereich. The male to female ratio can generally be viewed as 1,2: Modern planning and treatment techniques shall reduce long term side effects upon surrounding tissues and organs at risk. Within this group of children cases of spontaneous partial regression of hypothalamic and OPG have been clearly described and none in non-NF1 children.

End points of the trial For this subgroup of children the impact of intensifying the induction period of chemotherapy shall be investigated. For assessing response to chemotherapy in the randomised arms of the chemotherapy study all relevant scans have to be sent in for review during the pre-treatment and treatment periods.


The effects of chemotherapy on improving the actual clinical and neurological function, for efarbeiten the visual and endocrinological function for supratentorial midline tumors, and ultimately on health status HS and quality of life QoLhowever, deserve further investigation. Recommended frequency of ophthalmological examination during treatment and follow-up Lorenz It was for Italy, for the first German patients and for the United Kingdom.

Overview of protocol treatment section Measuring response by conventional criteria like complete or partial response does not seem appropriate for low grade astrocytoma, a phase of prolonged stable disease is an adequate success of therapy Packer By this, the committee hopes to meet the expectations of the study zahleenraum, pediatric cancer treatment centers and the patients and their families. Prolonged time intervals between courses during the continuation therapy To avoid increasing substantially the cumulative doses of the drugs chosen for the study when prolonging zahlebraum to 18 months, the time interval between courses during the continuationtherapy phase shall be extended to six weeks, analogous to other so-called maintenance treatments.

Frequency of examinations The consensus statement of the NF I optic pathway glioma task force Listernick suggests ophthalmological examinations for children with optic pathway gliomas every 3 months during the first year following diagnosis and six-monthly until 36 months and yearly thereafter. Thus changes for the newly defined patient subgroups are the following: Improvement of progression free survival following initial therapy is only a surrogate parameter of an improvement of the quality of life.

Qualitative changes of contrast enhancement will be described and correlated with response.