ABSTRACT. The present study aimed to evaluate the in vitro antimicrobial activity of pharmacologically important Adhatoda vasica plant extracts. Plant Adhatoda vasica L. Nees (Acanthaceae) commonly known as Malabar nut is an evergreen two – three m tall shrub, sometime used as. Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India. The alkaloid Vasicine was isolated from ethanolic extract of the .

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International Journal of Crude Drug Research. The free radical scavenging activity was calculated as follows: Extraction Shade dried and coarsely powdered leaves of A.

Estimates of worldwide burden of cancer in The compound showed prominent cytotoxic activity in vitro against A lung adenocarcinoma cancer cell line. Cytotoxic studies against A lung adenocarcinoma cancer cell line showed Vasicine acetate to be the most potent compound Table 4. HPLC analysis was carried out on a Waters Alliance separations module with photodiode array detector Waters, Preliminary phytochemical and antimicrobiwl screening of crude extract of the leaf of Adhatoda vasica.


The following Gram negative, Gram positive antimidrobial, clinical isolates, and fungi were used for the experiment: The combined chloroform extract was washed with water, dipped, and dried over anhydrous sodium sulphate. National Center for Biotechnology InformationU.

Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

The cytotoxicity was determined according to the method of Balachandran et al. Council of Scientific and Industrial Research; Support Center Support Center.

Every year, at leastpeople die worldwide from cancer related to their workplace [ vasixa ]. Introduction Natural products still remain the most important source for discovery of new and potential drug molecules. Microbial Organisms The following Gram negative, Gram positive bacteria, clinical isolates, and fungi were used for the experiment: A voucher specimen No.

Vasicine hydrochloride, a new drug for interruption of pregnancy. It was then distilled on a water bath and the residue was washed with little n-hexane.

Balachandran2 S. Vasicine showed antimicrobial activity against S.

The solutions were filtered through a membrane filter pore size 0. Conclusion Vasicine acetate was obtained by acetylation of Vasicine recovered from A. BHT is used as standard of antioxidant.

The ethanol extract of A. Then the residue was crystallised from chloroform to get Vasicine acetate as colorless crystals m. The crude extract of A. Sample ethanol extract Please review our privacy policy. The plant was identified by Dr. Minimum Inhibitory Concentration MIC Minimum inhibitory concentration studies of the compounds actifity performed according to the standard reference methods for bacteria [ 17 ] and filamentous fungi [ 18 ]. Classical Uses of Medicinal Plants.


The plant is reported to show abortifacient [ 7 ], antimicrobial adhattoda 89 ], and antitussive activities [ 10 ]. Table 4 Cytotoxic effect of Vasicine acetate against A lung adenocarcinoma cancer cell line. The plant contains alkaloids such as Vasicine, vasicinone, deoxyvasicine, vasicol, adhatodinine, and vasicinol [ 12 ].

Journal List Biomed Res Int v. Antibacterial and antifungal activities were carried out using disc diffusion method [ 16 ].

Antibacterial Activity of Leaf Extracts of Adhatoda vasica – MAHE Digital Repository

Published online Jan Abstract Adhatoda vasica L. Cytotoxicity of each sample was expressed as IC 50 value. Shade dried and coarsely powdered leaves of A.

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