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Between those extreme are many tissues that turn over on a time scale of years, although no direct measurements have been done. We use a simple cell population model to study how biological rhythms and the cell cycle interact to modulate the response to cancer therapy.
Multiscale modelling research theme Biological processes span several scales in space, from the single molecules to organisms and ecosystems.
However, the rate of renewal varies exerfices orders of magnitudes between blood cells, which are renewed every day and neurons, for which renewal is non-existent or limited to specific regions of the brain.
For slowly renewing tissues, this method provides a better estimate algwbre the average age of the tissue than direct estimate from the bomb curve. Multiscale modelling approaches in biology are useful to take into account the complex interactions between different organisation levels in those systems.
Biological processes span several scales in space, from the single molecules to organisms and ecosystems. Recent clinical trials have shown that chronotherapy can be beneficial in improving quality of life and median life span in patients, but that it can also have negative effects if altebre timing is wrong.
A theoretical basis for the rational development of individualized therapy schedules is still lacking.
exerccices Age distribution of DNA can be estimated from the integration of radiocarbon derived from nuclear bomb testing during Moreover, death, birth and turnover rates can be estimated. We are interested in approaches based on master equations for stochastic processes, individual-based models, hybrid continuous-discrete models and structured PDE models.
samuel bernard | mathematical biology
We have developed a mathematical method to estimate cell turnover in slowly renewing biological systems. Chronotherapy of cancers aims at exploiting daily physiological rhythms to improve anti-cancer efficacy and tolerance to drugs by administering treatments at a specific time each day.
A better understanding of the dyamical feature of clock regulation is important for designing individualized chronotherapy treatments. Chronotherapy of cancer research theme Chronotherapy of cancers aims at exploiting daily physiological rhythms to improve anti-cancer efficacy and tolerance to drugs by administering treatments at a specific time each day.
Estimating cell turnover research theme Human tissues continually replace dying cells with newborn cells. Human tissues continually replace dying cells with newborn cells.